Large Dispersion
Decreasing volume of the injected sample and increasing the volume of conduits between the injector and the flow cell will increase dispersion.
The concentration gradient will be shaped by conduit geometry, by conduit volume, and by flow rate.
In order to obtain very large D values, a mixing chamber can be integrated into the flow manifold.
1.2.11.
If the volume of a mixing chamber dominates the volume of the flow channel, the resulting concentration gradient has an exponentially decreasing trailing edge, with a wide range of increasing D values.
Systems with a large dispersion are used for process control monitoring where extensive sample dilution is required, and for flow-based titrations.
